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These oligonucleotides typically contain at least one region of modified nucleotides that confers one or more beneficial properties (such as, e.g., increased nuclease resistance, increased uptake into cells, increased binding affinity for the RNA target) and a region that is a substrate for RNase H cleavage

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All measurements were taken following the guidelines provided by the manufacturer

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At the same time, the drastic reduction of serum testosterone levels induced by ADT produces multiple side effects such as bone fracture, cardiovascular disease, sexual dysfunction anemia