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Maintenance doses are typically 1 mg every 2-3 months for life High-dose oral therapy (1000-2000 micrograms daily) may be effective in selected patients with pernicious anaemia under clinical supervision, as passive diffusion can compensate for absent intrinsic factor, though this is not routine first-line treatment in the UK The water-soluble nature of B12 means that high-dose supplementation carries minimal risk of toxicity , making it a safe option for individuals with confirmed or suspected deficiency

Exploring bidirectional causality between obstructive sleep apnea and chronic kidney disease via Mendelian randomization

Certain medical conditions should also be noted, such as kidney disease, low potassium and other nutritional deficiencies

The sub-classification into Specified or Non-Specified are important only in the sanctioning process

This is why managing symptoms promptly is important rather than simply tolerating them

Bologna, P