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Regardless of the labeling strategy, both require the enzyme terminal deoxynucleotidyl transferase (TdT) to catalyze the incorporation of the modified dUTPs to the 3-OH termini

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The discovery of CPPs dates back to 1988 when arginine-rich peptides were identified in the HIV-1 Tat protein that facilitated its entry into cells and translocation to the nucleus [117]

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