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Moreover, a clear association between lactylation modification and both heart failure and atherosclerosis has been established

Lake Forest, IL: Hospira

Consistent with this, patient-derived xenograft (PDX) models with genetic depletion or enzymatic degradation of GAGs exhibited reduced LDL uptake and impaired tumor growth, reinforcing GAG biosynthesis as a critical determinant of tumor growth by mitigating lipid oxidative stress

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