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doi: 10.1038/nrd2909 Summary Keywords antibody therapies, CD38 monoclonal antibodies, IgG Fc receptors, ectoenzymatic activity, multiple myeloma Citation Horenstein AL, Faini AC, Morandi F, Ortolan E, Storti P, Giuliani N, Richardson PG and Malavasi F (2025) Monoclonal anti-CD38 therapy in human myeloma: retrospects and prospects

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Upon binding to an uncharged tRNA, GCN2 undergoes a conformational change and is activated, resulting in inhibitory phosphorylation of eukaryotic translation initiation factor 2 (eIF2), preventing translation initiation under amino acid deficiency (Figure 1) (Berlanga et al., 1999