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Both prostacyclin and NO are endothelium-derived vasodilators that mainly play a role in vasodilation of the large arteries, while EDHF plays a role in the vasodilation of arteries less than 500 m in diameter, especially those less than 100 m in diameter (Rath et al., 2009)

242,243,244 Consistent with these findings, brain iron loading-mediated oxidative stress decreased the enzyme activity of DNMTs in mouse models, indicating an increase in the risk of neurodegeneration