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Ethical approval This study was conducted under the guidelines of the National Council for the Control of Animal Experimentation (CONCEA) and was approved by the Ethics Commission for Animal Use (CEUA) at Instituto Federal do Rio Grande do Sul campus Serto, RS, Brazil (Protocol number 1806240222)

Both native cardiac myocytes and pulmonary artery endothelial cells overexpressing AC6 are inhibited by the NO donor S-nitroso-N-acetylpenicillamine (SNAP), inhibiting both basal and FSK-stimulated cAMP production (Ostrom et al., 2004)

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Decades of research in pursuit of such a singularity has, however, uncovered common themes between select subgroups of mutant proteins, which may collectively be predictive of the propensity for all mutant proteins to misfold

Emerging literature suggests that immune cell mitochondrial health is compromised in PD models