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Asparagine suppresses the endoplasmic reticulum stress and regulates translation-dependent apoptosis during glutamine starvation, suggesting that asparagine may be a suppressor of apoptosis in cancer [69]

This observation may be partially attributed to the predominance of gynoid fat distribution localized to the hips, buttocks, and legs which has been associated with reduced insulin resistance when compared to central or android fat accumulation.15,25 Similarly, blood pressure measurements in women with early-stage lipedema tend to remain within normal ranges, with hypertension primarily observed in more advanced stages

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It is essential for regulating biosynthesis, transport, metabolic adaptability, organelle remodeling, and the maintenance of cellular component quality (Saha et al., 2018)

Abbreviations RA: Rheumatoid arthritis DSP: Dexamethasone sodium phosphate ChS: Chondroitin sulfate Gel: Nanogel EE: Encapsulation efficiency LE: Loading efficiency PDI: Polydispersity index LPS: Lipopolysaccharides CCK-8: Cell counting kit-8 RTCC: Rat cartilage cells CIA: Collagen-induced arthritis ELVIS: Extravasation across leaky vasculature followed by sequestration by inflammatory cells TNF-: Tumor necrosis factor alpha IL-1: Interleukin-1 IL-6: Interleukin-6 IL-10: Interleukin-10 CLSM: Confocal laser scanning microscopy H&E: Hematoxylin-eosin TB: Toluidine blue SO: Safranin O Micro-CT: Microcomputed tomography BMD: Bone mineral density BS/BV: bone surface area to bone volume BV/TV: Bone volume to the total volume Tb.N: Trabecular number Tb.Th: Trabecular bone thickness Tb.Sp: Trabecular separation ALT: Alanine aminotransferase AST: Aspartate aminotransferase CREA: Creatinine UREA: Urea References Wu D, Luo Y, Li T, Zhao X, Lv T, Fang G, Ou P, Li H, Luo X, Huang A, Pang Y