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doi: 10.1016/j.molonc.2012.02.007 104 ChambaCMawallaW

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LPS-treated hypercholesterolemic rabbits have increased atherosclerosis compared with controls [99] and mice lacking TLR4 have reduced atherosclerosis and plaques with decreased amounts of lipid [100]

Further mechanistic studies showed that DPD1 activation decreases IL-1 release and inhibits microglial activation and neutrophil infiltration by inhibiting pyroptosis and inflammation mediated by the NLRP3/caspase-1 pathway (83)

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Mitochondrial genetics Mitochondria are unique in possessing their own genetic material in the form of a double-stranded circular DNA molecule about 16 569 base-pair long