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In addition to ATF4, CHOP plays a critical role in regulating CHAC1 during UFR (Mungrue et al., 2009)

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The areas where their effects overlap are minimal

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In principle, as emphasized before (11), external fistulas form an anomalous connection between skin and gastrointestinal tract that provides a direct and unusual contact between these different, normally separated, tissues, thereby resulting in special new circumstances and healing difficulties, and a failure of regular healing that is otherwise not present