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This hypomethylated state was also detected in the forebrain region of rats born to fathers exposed to THC, supporting the potential for intergenerational inheritance of an altered sperm DNA methylation pattern. The Duke team found that there was a sex-based difference in the relationship between DNA methylation and gene expression in human brain tissues

Nicotine in tobacco smoke stimulates the sympathetic nervous system 12,63

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As a result, its essential to use e-cigs as a means to lower nicotine dependence gradually, rather than as a permanent solution