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Nat Rev Neurol 20 , 695707 (2024)

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

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Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase)

This might possibly be due to the engineered control circuits responding to the target product intermediate, limiting any improvement in production beyond initial control levels