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Given the extensive reprogramming of the AR cistrome towards non-canonical targets during progression to mCRPC 34,35 , these results suggest that NSD2 loss facilitates a shift towards a more canonical AR program

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The medication is eliminated primarily through protein breakdown rather than kidney excretion, so hydration does not accelerate the elimination process beyond supporting normal kidney function

Now that shes using tirzepatide, she said, she feels peace without the food noise and notes that part of what stopped it is a side effect of the medication: She physically feels kind of always bloated and not hungry. Summer Kessel, who has been using tirzepatide for over two years, said she was a bottomless pit who always felt hungry