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Importantly, we found that TGFb ligand treatment induced an up-regulation of the SNCA gene upon aSyn overexpression

The primary activities involve modulating transcription factors, regulating specific gene expression, and controlling cytoskeletal function, as well as balancing neurotransmitter levels and adjusting fluctuations in second messengers and protein kinases

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Furthermore, in liver, Chac1 protein is moderately expressed, whereas Chac2 protein is undetectable (21)

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