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159,160 GHD1 shRNA has no effect on PDAC cells growth, while knocking down GOT2 elevates ROS levels and leads to cell senescence

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More generally, how p53 pathway-dependent regulation of nucleotide metabolism links to the broader control of cell fate by p53 requires more detailed investigation

doi: 10.1371/journal.ppat.1000911 268 SaleemM.PrinceS