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The risk of severe GI events is increased by the presence of the following factors: history of peptic ulcer disease or GI bleed, smoking, alcohol usage, concomitant usage of anticoagulants, or oral corticosteroids, older age, and poor general health status

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The high specificity of peptide-receptor interactions often results in fewer off-target effects compared to small molecule drugs

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Molecular modifications are the primary driver of half-life engineering in modern peptide research

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