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The link of SLC7A11 to GPX4 is further determined [34], SLC7A11 mediates cystine uptake, subsequently, activates Rag-mTORC14EBP pathway-induced GPX4 protein synthesis

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849 In animal models of intestinal I/R, ferroptosis occurs primarily during the reperfusion phase due to the inactivation of the GSH/GPX4 pathway

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The second reason is based on several previous studies that assure the negative impact of these dosage levels on various organs of rats 33,34,35