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Of note is that the results of this trial are somewhat conflicting, and the study design does not allow the effects of riboflavin and niacin to be differentiated

In turn, LATS1/2 phosphorylation triggers YAP activation, causing YAP capture by 4-3-3 proteins in the cytosol or degradation by SCF-TRCP E3 ubiquitin ligase-mediated ubiquitin-proteasome signaling