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Additionally, the activity and function of glutamate transporters can be significantly affected by the severity of ischemic insult, with severe insults even causing a reversal in glutamate transport due to disruptions in the ionic gradients that drive these transporters [167]

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In HFD-fed mice, the treatment demonstrated improvements in glucose tolerance, reduced hepatic steatosis, and alleviated adipose inflammation, partially by restoring oxidative stress, inflammation, and ERSrelated gene expression through SIRT1 (Yoshino et al

Therefore, to demonstrate whether adipocytes can undergo apoptosis in response to oxidative stress, one study treated mature adipocytes with H 2 O 2 and found that an increase in ROS enhanced adipocyte apoptosis (80)