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Injection-Based Administration Subcutaneous injections: All GLP-1 RAs are administered via subcutaneous injection Prefilled pens: Most common delivery system, allows for self-administration Auto-injectors: Simplify the process for patients with dexterity issues Multi-dose pens: Require dose dialing and needle attachment Dosing frequency: Daily: Liraglutide (Saxenda, Victoza), some formulations of exenatide (Byetta) Weekly: Semaglutide (Wegovy, Ozempic), tirzepatide (Mounjaro, Zepbound), dulaglutide (Trulicity), exenatide extended-release (Bydureon) Titration schedules: Most FDA-approved GLP-1 RAs require gradual dose escalation to minimize gastrointestinal side effects

Those with liver disease or who consume alcohol regularly should use lower doses and consult their healthcare provider

Weekly injections are often recommended initially, with the option to transition to monthly maintenance treatments

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Therefore, this study confirmed that the SELECT study reaffirms the long-term safety profile observed in previous studies, without identifying any novel safety concerns for OW 2.4 mg semaglutide

Greene CE, Schultz RD (2005): Immunoprophylaxis and immunotherapy