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According to qualitative and quantitative experimental data that were evaluated, GSH conjugation is the first upstream Key Event (KE) of this AOP, triggering oxidative stress (OS)

List of studies Overview of EpitalonHighly Bioactive Pineal Tetrapeptide with Promising Properties Type of study: literature review Number of citations: 1 Year: 2025 Authors: Szymon Kamil Araj, Jakub Brzezik, Katarzyna Mdra-Gackowska, ukasz Szeleszczuk Journal: International Journal of Molecular Sciences Journal ranking: Q1 Key takeaways: Epitalon shows significant geroprotective and neuroendocrine effects, with potential mechanisms including antioxidant, neuro-protective, and antimutagenic effects

Zhang J, Wang S, Jiang B, Huang L, Ji Z, Li X, et al

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Mitochondrial quality control mechanisms, including mitophagy and fission/fusion dynamics, are essential at this stage to prevent chronic ROS leakage and restore redox homeostasis

These animals also showed improvement in spatial learning and memory abilities in addition to reduced autophagy activation (Zhang et al., 2010)