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Abstract Ionizing radiation generates DNA double-strand breaks (DSBs) that challenge DNA repair mechanisms and drive mutagenesis, chromosome rearrangements, and cell lethality

Previously, we have shown that neither TrxR2 mRNA nor TrxR3 mRNA are induced in TrxR1-deficient embryos (Bondareva et al., 2007) or livers (Suvorova et al., 2009), indicating that there is not an induction of the genes encoding either of the other known TrxRs that might compensate for ablation of TrxR1

Integration of network pharmacology and transcriptomics to explore the mechanism of isoliquiritigenin in treating heart failure induced by myocardial infarction

Ankersen, and P