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Additionally, one clinical trial by Douglas Greig et al

Changes in LOC may reflect diminished perfusion to the CNS during ischemia or infarction

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however, elevated levels of serum IGFBP-1 and IGFBP-3 were found higher in the transplant patients with erythrocytosis, which have been related to decreased degradation of IGF-1.129 In addition, recombinant EPO administration increased IGF-1 levels in hemodialysis patients, along with higher serum collagen telopeptide concentration, in comparison with untreated patients

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