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Age-related macrophage alterations are associated with carcinogenesis of colorectal cancer

May 2021 College of Medicine Tucson Research Day 2021, University of Arizona, USA, Williams DEJ , King K, Jackson R, Rodriguez A, Van Doorslaer K Role of PRMT-1 in Persistent HPV Infection Apr 2021 Tim & Diane Bowden Research Symposium 2021, University of Arizona, USA, Williams DEJ , King K, Jackson R, Rodriguez A, Van Doorslaer K Single Cell Sequencing Identifies a Role for Arginine Methylation in Persistent HPV Infection Apr 2021 Discover BIO5: Research to Innovation Showcase University of Arizona, USA, Jackson R, Williams D , aniewski P, McKenzie R, King K, Herbst-Kralovetz MM, Van Doorslaer K

GSH exists in cells mostly in the reduced form (GSH) which is constantly oxidized forming oxidized GSH and its supply is replenished by the action of GSH reductase

Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimers disease

By contrast, increasing GSH results in decreased SOCE

In models of viral infection, the expansion of GLS-deficient CD8+ T cells was significantly reduced, further underscoring the importance of GLS activity in CD8+ T cell function