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In this context, NRF2 inhibition leads to the upregulation of miR-181a-2-3p, which directly targets HIF-2, consequently resulting in the attenuation of the HIF-2-mediated CSC phenotype in colorectal cancer cells (Fig

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The overwhelming ERS results in tubular cell injury and ultimately contributes to the progression of kidney damage (79)

In addition to their potent antioxidant activities, these nutraceuticals also provide significant health benefits through their anti-inflammatory properties

type I IFN enhances NK cell killing function through the cGAS-STING pathway while inhibiting Treg activity, thereby reversing immune suppression and restoring the bodys antitumor capacity