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The finding that cocaine self-administration in adolescents is mediated by D 2 receptors is in marked contrast to adults, where D 1 receptors mediate cocaine reinforcement ( 2 receptors do not mediate cocaine self-administration in adults but are, instead, involved in mechanisms that limit intake of high-dose cocaine ( As shown in the present study, fluoxetine and nicotine enhancement of DA-mediated behaviors in adolescents are mediated by functional sensitization of both 5-HT 1A R and D 2 receptors

In particular, nicotine replacement therapy (NRT) and other cessation aids can be useful for helping people quit smoking

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