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A number of researchers have reported that the activation of the SphK1/S1P signaling pathway marks the occurrence of autoimmune diseases, and the up-regulation of SphK1 is related to the pathogenesis of multiple sclerosis (Luo et al., 2017)

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Corsini EM, Mitchell KG, Mehran RJ, Rice DC , Sepesi B, Walsh GL, Swisher SG, Roth JA, Hofstetter WL, Vaporciyan AA, Antonoff MB

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