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Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use

According to NICE Clinical Knowledge Summaries and the British National Formulary , the standard treatment is intramuscular injections of 1,000 mcg (1 mg) hydroxocobalamin

Seek immediate medical attention if you suspect an overdose

These treatments are Health Canadaapproved and work by targeting overactive nerve signals to provide symptom relief

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Do acid-lowering agents affect vitamin B12 status in older adults