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For instance, GBM acquires resistance to TMZ through alterations in their expression of DNA alkylating proteins, DNA repair enzymes, as well as cell signaling pathways [17]

To prevent IMR-5/75 from detaching, the plates were treated beforehand with 100 g/mL Poly-D-Lysine (Sigma-Aldrich)

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4.3 Pharmacokinetic parameters in Sprague-Dawley rats after intravenous and intramuscular administration A total of 324 SD rats were randomly divided into five groups, including 66 rats in group one, 60 rats each in groups two to four, and 78 rats in group five, with each group comprising half male and half female subjects