Mumford SL, Browne RW, Kim K, et al
By directly binding RAF-1 and MEK, RKIP interferes with the formation of the kinase-substrate complex, thereby inhibiting the phosphorylation of MEK, ultimately plays a role in inhibiting RAF/MEK/ERK signaling pathway
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In laying hens, chronic heat stress-induced renal fibrosis is potentially promoted by indoxyl sulfate
It was therefore called the enzyme of life
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