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Recently, glutamine-related metabolic pathways, such as the glutamine-glutamate-GSH pathway, glutamine-glutamate--KG-2-HG pathway, and glutamine-mTOR signaling, which participate in regulating Th17/Treg cell differentiation, have been identified (56)

Apart from TJ disruption, increased epithelial cell death directly leads to the loss of barrier function

M., Mikhael, P

Biochim Biophys Acta (2009) 1790(11):145362

C-reactive protein: risk marker or mediator in atherothrombosis

in a rat model of hepatocellular carcinoma, apigenin increased MMP, ROS level, mitochondrial swelling, and cytochrome c release leading to apoptosis only in cancerous hepatocytes [176]