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Although AC has demonstrated promising pharmacological activities in a wide range of in vitro and in vivo models, its clinical evaluation remains relatively limited

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First, only a limited number of the studies have assessed the effects of NAC on progesterone and SHBG levels

Human gut microbiota has gained much attention due to increasing evidence of compositional and structural changes of gut microbiota playing a vital role in various aspects of human health, including immune, metabolic, and neuro-behavioral traits (50)

Also, IM is not necessary at all, as B12 has a long, documented history of effective SQ delivery

BMC Biotechnol 4:32 Acknowledgments The authors would like to thank Huira Chong and Jennifer Aurandt for critical review of the manuscript