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This elevation in BDNF levels could reverse the inflammatory environment induced by LPS exposure in microglia and be transferred to neurons through microglianeuron interactions, thereby promoting the recovery of impaired synapses and alleviating neuronal damage [56]

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PRKDC PRKDC has emerged as a radiotherapy resistance driver gene in GBM from a OCT perturb-seq screen, and a driver of chemotherapy resistance in neuroblastoma in a targeted CRISPR screen [40, 78]