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Description

ER stress and UPR activation in glioblastoma: identification of a noncanonical PERK mechanism regulating GBM stem cells through SOX2 modulation

The combination is named for Dr

In these contexts, astrocytes may shift from a neuroprotective role to one that exacerbates neuronal dysfunction, potentially due to downregulated expression of lactate dehydrogenase A (LDHA), a key glycolytic enzyme, which impairs lactate shuttling by inhibiting large conductance Ca 2+ activated potassium channel (BK channel)-mediated neuronal hyperpolarization (Yao et al., 2023)