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Through this mechanism, the buildup of -catenin triggers target genes that modulate the cell cycle, hence influencing ISC activity

By integrating these mechanistic insights with therapeutic innovation, the field is shifting from a narrow focus on glucose lowering to a broader approach aimed at preventing and potentially reversing the vascular complications of diabetes

The main mechanisms include stimulating the expression of follicle-related growth factors, dilating scalp blood vessels and improving microcirculation, boosting the differentiation and proliferation of hair follicle epithelial cells, and activating the Wnt/-Catenin signaling pathway and its key proteins (Scheme 2)