Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan deuterium-labeled-ether S)-AHPC-acetamido-O-PEG2-OH Synonyms CAS Number n/a

S)-AHPC-acetamido-O-PEG2-OH Synonyms CAS Number n/a Related CAS Molecular Formula C28H40N4O7S Molecular Weight 576

2341796-77-6 (2HCl salt) Molecular Formula C29H45Cl2N5O4S Molecular Weight 630

Molecular Weight Cannot read molecule file

118 Purity (HPLC) >= 95% Solubility DMSO

58 SMILES [2H]C([2H])([2H])OC1=CN=C(Cl)N=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan deuterium-labeled-ether S)-AHPC-acetamido-O-PEG2-OH Synonyms CAS Number n/aSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I