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Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model

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As the prenatal essence is inherited from parents and hence cannot be replenished after birth, a sufficient supply of postnatal essence is needed to minimize the utilization of prenatal essence for the generation of Zheng Qi

doi: 10.3389/fcell.2016.00016 Received 29 November 2015 Accepted 22 February 2016 Published 23 March 2016 Volume 4 - 2016 Edited by Gaetano Santulli, Columbia University in the City of New York, USA Reviewed by Yves Combarnous, Centre National de la Recherche Scientifique, France

Future research should focus on elucidating the molecular mechanisms of this interaction and exploring novel therapeutic agents targeting those pathways

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