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ROS directly damage IECs, activate mucosal immune responses, and trigger oxidative stress-related signaling pathways such as NF-B and nuclear factor erythroid 2-related factor 2 (Nrf2), thereby aggravating barrier dysfunction and chronic inflammation (100, 101)

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Current evidence suggests that cortisone can improve pain and function for up to 3 months, but in some cases, it can last longer

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Probably something similar to what we're going to talk about

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