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Nicotine facilitates increased dopamine in the cortex similarly to observations in subcortical regions in that the drug binds high-affinity nAChRs on dopamine neurons that project from the VTA, but in this case toward the cortex, and binds low-affinity receptors on excitatory glutamatergic neurons projecting toward the prefrontal cortex (99, 100)

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The standard cigarette was sold at a low cost and was easily obtainable, since it was sold in government retail shops and cooperatives

317329, doi:10.1016/b978-0-12-819973-2.00030-7, ISBN 978-0-12-819973-2, PMID 34266602, retrieved 2024-12-26 Preventing Anosmia from Intranasal Zinc Administration "Anosmia induced by amiodarone"