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KEAP1 acts as a negative regulator of NRF2

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These nutraceuticals have some mechanisms of action in common, including the inhibition of ACE, the enhancement of NO-mediated vasodilation, interactions with ion channels including the blocking of calcium channels and opening of potassium channels with consequent membrane hyperpolarization, anti-inflammatory effects with reductions in synthesis and release of pro-inflammatory cytokines, and enhancement of endogenous antioxidant actions exerted by different enzymes, such as SOD, GPx, and GSTP

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Portal L, Martin V, Assaly R, dAnglemont de Tassigny A, Michineau S, Berdeaux A, Ghaleh B, Pons S (2013) A model of hypoxia-reoxygenation on isolated adult mouse cardiomyocytes: characterization, comparison with ischemia-reperfusion, and application to the cardioprotective effect of regular treadmill exercise

doi: 10.1038/s41586-019-1705-2 61 DollSFreitasFPShahRAldrovandiMda SilvaMCIngoldIet al