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Abbreviations %: Percentage m: Micrometer ADA: American Diabetes Association ALO: Aloperine ATP: Adenosine triphosphate cAMP: Cyclic adenosine monophosphate CRP: C-reactive protein DKA: Diabetic ketoacidosis DM: Diabetes mellitus DPP-IV: Dipeptidyl peptidase-IV GAD: Glutamic acid decarboxylase GLP-1: Glucagon-like peptide-1 GLUT-4: Glucose transporter type 4 GPx: Glutathione peroxidase GSH: Glutathione HDL: High-density lipoprotein IL-1: Interleukin 1 IRS-2: Insulin receptor substrate-2 LDL: Low-density lipoprotein MAMs: Mitochondria-associated membranes NIDDM: Non-insulin dependent diabetes mellitus nm: Nanometer OS: Oxidative stress PDX-1: Pancreatic and duodenal homeobox-1 PI3K: Phosphatidylinositol 3-kinase PKC: Protein kinase C PPAR-: Peroxisome proliferator-activated receptor- ROS: Reactive oxygen species SOD: Superoxide dismutases STZ: Streptozotocin T1DM: Type 1 diabetes mellitus T2DM: Type 2 diabetes mellitus TNF: Tumour necrosis factor-alpha References Ojo OA, Ibrahim HS, Rotimi DE, Ogunlakin AD, Ojo AB

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found that metformin inhibits the palmitic acid (PA)-induced upregulation of periostin (POSTN), which in turn increases p53 expression in VSMCs