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At 48 h, plates were replenished with media treated with e-cigarette extracts or treated with e-cigarette extracts and cisplatin

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The difference between the e-cigarette group and the never smoker group in thrombospondin-1 levels was comparable to the difference between the tobacco smoker group and the never smoker group

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This is due to the fact that the model-based estimators borrow strength from similar domains to overcome the lack of observations in smaller states/territories and increase the effective sample size to obtain better accuracy in the estimated trends

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