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In fact, research suggests that glutathione deficiency is a secondary effect of having low G6PD levels

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Oncolytic viruses Oncolytic viruses (OVs) represent a promising therapeutic strategy for GBM, leveraging their ability to selectively infect and lyse rapidly proliferating tumor cells while transforming the immunosuppressive TME into an immune-responsive state

Similarly, in breast cancer, LOH at this locus occurred in approximately 36% of breast cancer tissues, and GPx1 with a leucine-containing allele exhibited lower GPx1 activities in response to stimulation than GPx1 a proline-containing allele [88]

It should be emphasized that not all ROS equally contribute to the occurrence of ferroptosis, despite its initiation being attributed to oxidative damage [53]