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This is the point where you start to feel good, and this is the main thing that keeps you hooked.' Essentially, nicotine enters your brain's reward pathway and starts releasing dopamine and serotonin within 10 to 20 seconds of the first drag, giving you a very rapid pleasure response associated with smoking

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First, although participants were randomly assigned to intervention groups, the randomization procedure was relatively simple and may not fully eliminate allocation bias

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