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Research indicates that employees who smoke often take multiple smoke breaks throughout the workday, with each break typically lasting between 5 to 15 minutes

After 32 weeks or at the time of disease flare during the DB phase, subjects were treated in the open-label extension phase based on the BSA regimen (OLE-BSA), before converting to a fixed dose regimen based on body weight (OLE-FD phase)

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Globally, a similar pattern can be seen