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These regions were chosen because of their putative role in the neural mechanisms of ME/CFS and long COVID, in particular with regard to the integration of information from various levels [33, 34], with pgACC key for emotional regulation and autonomic integration, and dACC - for cognition [35, 36]

ATAC-seq and ChIP-seq analyses revealed extensive reorganization of enhancer landscapes, redistribution of histone modifications, including H3K4me3 and H3K27ac, and altered transcription factor accessibility