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Under pathological conditions (such as ischemia and hypoxia), transporter proteins are increased or decreased and become aberrantly activated or inactivated, causing metal overload or deficiency and affecting many cellular signaling

Under this hypothesis, the increased signal is more likely to reflect non-G4 structural reorganization rather than G4 formation

The pathologic process of epicondylitis involves chronic degenerative changes of the tendons (tendinosis) at the region of the respective epicondyles

Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice

Thus, our study adds to the growing body of evidence supporting the clinical translation of targeting LDHB alone or combined with radiotherapy and other ferroptosis-inducing therapies

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