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It has been found that mitochondrial fission occurs at the contact points between the OMM and endoplasmic reticulum (ER) tubules, which are determined prior to the recruitment of DRP1 ( In vitro experiments have confirmed that knockdown of INF2 and Spire1C lead to elongated mitochondria and reduced binding of DRP1 to mitochondria ( 2+ into mitochondria, leading to a change in mitochondrial membrane potential and contraction of the inner mitochondrial compartment ( Mitochondrial fusion-related proteins play a crucial role in maintaining mitochondrial integrity and function

Thus, recognizing these factors that play a role in the development of the disease is essential for preventing the progression of MS