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Activation of endogenous antioxidants: the core antioxidant system The Kelchlike ECHassociated protein 1 (Keap1)nuclear factor erythroid 2related factor 2 (Nrf2)antioxidant response element (ARE) pathway is the center of the biological response to oxidative stress, regulating a variety of cell-protecting proteins (also known as phase 2 enzymes) to maintain the homeostasis of ROS levels in cells [98,99,100,101,102]

Abbreviations CA cornu ammonis CAT catalase DG dentate gyrus GSH glutathione LTP long-term potentiation mHtt mutant Huntington protein Nrf2 nuclear factor erythroid 2related factor PD Parkinson disease PFC prefrontal cortex RNS reactive nitrogen species ROS reactive oxygen species SOD superoxide dismutase Authorship Contributions Wrote or contributed to the writing of the manuscript: Salim

I., & Baker, S

This suggests that a proper balance is needed amino acid sufficiency keeps GCN2 activity in a beneficial range that supports osteoblast precursor proliferation via ATF4-driven nutrient uptake, whereas an insufficiency would over-activate GCN2s stress response and stall cell cycling [141]

This makes H

Available inducers (e.g., erastin, RSL3, elesclomol) often suffer from poor pharmacokinetics, limited tumor selectivity, and narrow therapeutic windows, leading to potential off-target toxicity