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We included SRs with or without meta-analyses that evaluated the effect of e-cigarettes on the risk of CVD

It is well-known that smoking increases mortality, however to date, estimates of the number of Australian deaths caused by smoking have been based on international studies, as local data have not been available

While this approach seems to be safe, a Cochrane review of five randomised controlled trials found no clear evidence of superiority of dual patching over single patch (risk ratio [RR]: 1.09

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